Figure 6.

V₁ agonist-induced decrease of IL-1β detected in the medium of cortical astrocytes and its dependence on CREB activation. Astrocytes were treated according to the indicated conditions for 24 hr followed by medium collection and ELISA analysis on IL-1β. Results are expressed as mean ± SEM percentage change of IL-1β level in the medium relative to control (CTRL) and are representative of three separate experiments. n = 3 for each condition; ^*p < 0.05 versus control; ⁺p < 0.05 versus LPS-treated culture. The measured value for the control IL-1β level in the medium was 131.43 ± 9.09 pg/ml.