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. 2004 Mar 3;24(9):2112–2121. doi: 10.1523/JNEUROSCI.4645-03.2004

Figure 6.

Figure 6.

LTD at CP-AMPAR synapses involves a reduction in transmitter release. A, Top, EPSCs recorded at holding potentials between -60 and +40 mV (left) and the corresponding I-V relationship (right). An inwardly rectifying I-V relationship suggests that this synapse comprised CP-AMPARs. dl-APV was included for the entire period of the experiment to isolate CP-AMPAR-dependent LTD. Middle, Averaged current traces from 10 EPSCs taken at the time points indicated in the dot plot (bottom). The right traces show the normalization of control EPSCs (1) and the EPSCs recorded in the presence of γ-DGG (2 and 4). Bottom, Time course of inhibition by γ-DGG (1 mm) (2 and 4) before (1) and (3) after induction of LTD from six neurons. B, EPSCs recorded during the two applications of γ-DGG were normalized to their respective controls for ease of comparison of the degree of γ-DGG block before and after the induction of LTD. C, γ-DGG-mediated inhibition from six individual CP-AMPAR synapses before and after the induction of LTD. The filled circles are averages of γ-DGG inhibition before and after the induction of LTD. Open circles are data obtained from individual experiments. Note that the percentage of inhibition by γ-DGG was significantly increased after the induction of LTD at CP-AMPAR synapses.