Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2004 Feb 18;24(7):1673–1679. doi: 10.1523/JNEUROSCI.5214-03.2004

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2004 Society for Neuroscience 0270-6474/04/241673-07.00/0

PMC Copyright notice

Figure 2. — Intracellular, but not extracellular, application of AMT inhibitors blocks striatal LTD. a, Including the AMT inhibitor VDM11 (10 μm) intracellularly via the patch pipette blocked LTD (•), whereas a similarly included vehicle (0.02% DMSO) had no effect (○). Top, Sample traces for VDM11 inside (top) and vehicle inside (bottom); traces are as in Figure 1. b, LTD was also blocked when AM404 (2 μm) was included intracellularly. Top, Traces are as in Figure 1. c, Slices pretreated extracellularly with VDM11 (10 μm) expressed LTD. Top, Traces are as in Figure 1. Calibration: 100 pA, 25 msec. d, PPR of EPSCs 20-30 min after HFS relative to baseline (percentage). Vehicle (Veh)-loaded cells and cells pretreated extracellularly with VDM11 (VDM11 out) exhibited enhanced PPR after HFS. Cells loaded intracellularly with either VDM11 (VDM11 in) or AM404 (AM404 in) did not exhibit this PPR increase.