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. 2019 Aug 30;10:747. doi: 10.3389/fgene.2019.00747

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Copyright © 2019 Dahlin, Holkenbrink, Marella, Wang, Liebal, Lieven, Weber, McCloskey, Wang, Ebert, Herrgård, Blank and Borodina

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway for fatty alcohol production; a simplified pathway for the metabolic conversion of glucose into fatty alcohols in S. cerevisiae and Y. lipolytica. Color-coded text and arrows: red, pathway in Saccharomyces cerevisiae; blue, pathway in Yarrowia lipolytica; green, heterologous reactions. The red X-symbol signifies corresponding gene knockouts. Abbreviations: ACL, ATP citrate lyase; ACS, acetyl–CoA synthase; ACC, acetylCoA carboxylase; FAS, fatty acid synthase complex; FAR, fatty acyl–CoA reductase; PEX10, peroxin 10; FAO1, fatty alcohol oxidase; HFD1, fatty aldehyde dehydrogenase 1 (ALDH1); HFD4, fatty aldehyde dehydrogenase 4 (ALDH4).