FIGURE 6.

gp120tg mice show impairments in a task of spatial navigation. 8–10 month-old mice were evaluated with the Morris water maze (MWM) navigation task. (A) Latency to locate the submerged escape platform in the maze over five training days of acquisition and five days of reversal learning. These two learning phases were separated by a probe (P) on day 6 and a reversal probe on day 12. One-way ANOVA (within each TD) with Tukey’s HSD. Each data point represents the genotype mean of the average of an animal’s trials on a training day. (B) Duration in the target quadrant during the first probe trial. Dotted line indicates chance performance. One-way ANOVA with Tukey’s HSD. (C) Passes over the former location of the target platform during the probe trial. Kruskal–Wallis with post hoc Dunn’s. (D) Duration in the reversal target quadrant during the first probe trial. Dotted line indicates chance performance. One-way ANOVA with Tukey’s HSD. (E) Passes over the former reversal escape during the reversal probe trial. Kruskal–Wallis with post hoc Dunn’s. (F) Habituation swim speed and (G) percent of first trial in the center of the MWM were taken as control measures for locomotion and motivation to explore the maze, respectively. One-way ANOVA. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. Data are displayed as mean ± SEM. n = number of animals per group.