. 2019 Aug 14;32(4):e00007-19. doi: 10.1128/CMR.00007-19

TABLE 11.

Amino acid changes described in transferable OqxA^a

Yr^c	GenBank accession no.^b		% identity^d	Amino acid difference													Gram-negative genus or genera^e	Reference^f
Yr^c	DNA	Amino acid	% identity^d	Amino acid difference													Gram-negative genus or genera^e	Reference^f
2007	EU370913 ^g	AAP43109	100.0	G₈	G₁₆	M₁₉	S₃₀	A₁₁₃	R₁₁₆	I₁₅₉	S₁₈₃	A₁₉₉	Q₂₄₄	R₃₃₈	D₃₃₉	ins	Enterobacter, Escherichia, Salmonella, Shigella	156
2012	NG_050420	WP_063865358	99.7							V							Escherichia, Raoultella, Salmonella, *Enterococcus*	177
2016	NZ_LVMD01000084	WP_063501637	99.7		S												Escherichia
2016	KT727030	AMW92379	99.7				R										*Enterococcus*
2018	CP029215	AWJ07841	99.7												E		Escherichia
2018	CP026492	AUY47426	99.7			I											Escherichia
2018	KT716392	AMW92376	99.7										H				*Enterococcus*
2016	FLWH01000008	SBY67709	99.5	E						V							Escherichia
2017	NZ_MKFO01000039	WP_089069082	99.5					E		V							Escherichia
2017	MOGH01000057	OJM31094	99.5							V	R						Escherichia	56
2018	JAMW01000061	OXY63391	99.5						K	V							Salmonella
2018	MG028668	AWG41968	99.5							V		T					Enterobacter
2018	MG028669	AWG41969	99.5							V				C			Enterobacter
2018	PTMN01000089	PPW02434	99.2													₄₁PAP	Escherichia

Gram-positive microorganisms are highlighted in boldface type. No allelic numeration has been included to avoid confusion with a series of K. pneumoniae chromosomal OqxA proteins that are present in GenBank with an assigned allelic numeration. Note that these variants may be present in other genera and that other OqxA variants may remain undetected. ins, insertion.

In several cases, multiple valid DNA/amino acid sequences may be found in GenBank.

Date of first published report. If no published report has been found, the data for the older GenBank record are reported.

The minimum degree of identity considered was 99%. A series of OqxAB efflux pumps with lower levels of identity are present in GenBank, including a transferable oqxAB gene probably derived from an ancestral K. aerogenes isolate (GenBank accession number NZ_BGTY01000006) (see “OqxAB”).

In all cases, it is considered that any OqxA reported in a microorganism other than Klebsiella spp. belongs to a transferable gene, irrespective of chromosomal/plasmid location or the absence of specific genetic environment data. The presence of transferable OqxA in Klebsiella spp. is not reported here.

First published report.

First OqxA described as a transferable determinant.