Table 2.

Performances of eGFR and functional magnetic resonance imaging measurements for the differentiation of ≤25% versus >25% interstitial fibrosis and >50% versus ≤50% interstitial fibrosis among kidney transplant patients with allograft injury

Measurements	Correlations with Interstitial Fibrosis	≤25% versus >25% Interstitial Fibrosis				>50% versus ≤50% Interstitial Fibrosis
		Cutoff	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	Cutoff	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)
Apparent diffusion coefficient	rho=−0.77; P<0.001	1.99×10−3mm2/s	0.87 (0.79 to 0.93)	76% (62% to 87%)	84% (70% to 93%)	1.91×10−3mm2/s	0.88 (0.80 to 0.93)	86% (64% to 97%)	72% (61% to 81%)
Arterial spin labeling	rho=−0.83;; P<0.001	101 ml/min per 100 g	0.92 (0.85 to 0.97)	94% (85% to 99%)	78% (63% to 88%)	82.9 ml/min per 100 g	0.94 (0.87 to 0.98)	95% (76% to 99.9%)	87% (77% to 93%)
Perfusion fraction	rho=−0.66 P<0.001	0.299	0.81 (0.72 to 0.88)a	76% (62% to 87%)	78% (63% to 88%)	0.285	0.86 (0.78 to 0.92)	91% (70% to 99%)	72% (61% to 81%)
BOLD	rho=0.61; P<0.001	18.10 Hz	0.79 (0.69 to 0.87)b	79% (64% to 89%)	72% (57% to 84%)	18.14 Hz	0.85 (0.76 to 0.92)	91% (70% to 99%)	69% (58% to 80%)
eGFRc	rho=−0.79; P<0.001	38 ml/min per 1.73 m2	0.91 (0.84 to 0.96)	91% (80% to 97%)	78% (63% to 88%)	38 ml/min per 1.73 m2	0.91 (0.84 to 0.96)	95% (76% to 99.9%)	72% (61% to 81%)
eGFRd	rho=−0.79; P<0.001	38 ml/min per 1.73 m2	0.93 (0.85 to 0.97)	89% (77% to 97%)	83% (69% to 92%)	38 ml/min per 1.73 m2	0.90 (0.82 to 0.95)	95% (76% to 99.9%)	68% (56% to 79%)

eGFR calculated by the CKD Epidemiology Collaboration equation AUC, area under the curve; 95% CI, 95% confidence interval; BOLD, blood oxygen level–dependent.

^aRepresented P<0.05 by comparing the AUC of perfusion fraction to that of eGFR.

^bDenoted P<0.01 by comparing the AUC of BOLD to that of eGFR.

^cIndicated that data were analyzed from all 103 patients with allograft injury.

^dDenoted that data were analyzed from 93 patients with BOLD results.