Table 3.
Immunohistochemical characteristics of fresolimumab-induced neoplasms
| Patient | Location | Ki-67 | P53 | HL | HH | Diagnosis | Comments |
|---|---|---|---|---|---|---|---|
| 007 | Skin, ear | + | – | – | – | KA | |
| Skin, ear | ++ | – | – | – | KA | ||
| Skin, submandibular | ++ | – | – | – | KA | ||
| Skin, neck | 0 | 0 | – | ++ | KA | ||
| Skin, forearm | 0 | 0 | + | – | KA | ||
| Skin, shoulder | + | – | – | – | KA | Probably early lesion | |
| Skin, lateral eye | ++ | – | – | – | pilomatricoma | ||
| 018 | Skin, forearm | ++ | ++ | – | – | Hypertrophic Actinic keratosis | |
| Skin, preauricular | 0 | 0 | – | – | KA | ||
| Skin, distal arm | + | + | – | – | KA | ||
| Skin, clavicle | ++ | – | – | – | KA (atypical) | ||
| Skin, clavicle | ++ | + | – | – | KA | ||
| Skin, post-auricular | ++ | + | – | – | SCC microinvasive | Some features of KA. Central review different from local site diagnosis of KA | |
| Skin, thigh | + | – | – | + | KA | ||
| Skin, shoulder | 0 | 0 | – | – | KA | ||
| Skin, subscapular | + | – | – | + | KA | ||
| Skin, parascapular | + | – | – | – | KA | ||
| 009 | Skin, mid-back | + | ++ | – | – | KA (atypical) | Central review different from local site diagnosis of SCC |
Ki67, MIB1 proliferative marker; +, low proliferation mostly at the periphery of the lesion; ++, high proliferation seen in growing phase of SCC or keratoacanthomas; P53, oncogene expressed only on mutant keratinocytes; HL, low-risk HPV mRNA by in situ hybridization; +, trace of uncertain significance; ++, positive focally; HH, high-risk HPV mRNA by in situ hybridization (HPV 16/18/33 are associated with certain SCC especially in mucosal surfaces), +, trace; ++, positive