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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Transl Perioper Pain Med. 2019 Aug 14;6(4):106–114. doi: 10.31480/2330-4871/097

Figure 2.

Figure 2.

Effect of intrathecal pre-administration of BIX01294 (BIX) on the CCI-induced pain hypersensitivities during the development period. BIX01294 at the dose of 2.5 μg or saline was administered intrathecally starting 30 min before CCI surgery and once daily for 6 days after CCI surgery. Behavioral tests were carried out one day before CCI surgery and on days 3, 5, and 7 post-CCI. (A, B) Effect of BIX01294 or saline on paw withdrawal thresholds (PWTs) to mechanical stimulation on the ipsilateral (A) and contralateral (B) sides. (C, D) Effect of BIX01294 or saline on paw withdrawal latencies (PWLs) to thermal stimulation on the ipsilateral (C) and contralateral (D) sides. (E) Effect of BIX01294 or saline on paw withdrawal latencies (PWLs) to cold stimulation on the ipsilateral side. N = 8 rats/group. **P < 0.01 vs. the saline-treated CCI rats at the corresponding time points by two-way RM ANOVA followed by post hoc Tukey test.