Table 1.

Definitions of Pancreatitis in Children (INSPPIRE Criteria)⁹

	Clinical Definition
AP	Requires ≥2 of 3 criteria: 1. Abdominal pain suggestive of or compatible with AP 2. Serum amylase and/or lipase activity ≥3 times greater than upper limit of normal 3. Imaging findings characteristic of or compatible with AP
ARP	Requires ≥2 episodes of AP plus Complete resolution of pain (≥1-mo pain-free interval between diagnoses of AP) OR Complete normalization of amylase and lipase between episodes
CP	Requires ≥1 of the following 3 criteria: 1. Abdominal pain consistent with pancreatic origin and imaging findings suggestive of CP damagea 2. Evidence of EPI and suggestive pancreatic imaging findingsa 3. Evidence of endocrine pancreatic insufficiency and suggestive pancreatic imaging findingsa

^a“Suggestive” imaging findings of CP include ductal changes (irregular contour of the main PD or its radicles; intraductal filling defects; calculi, stricture, or dilation) and parenchymal changes (generalized or focal enlargement, irregular contour [accentuated lobular architecture], cavities, calcifications, heterogeneous echotexture).