Table 1.
Baseline characteristics of patients at time of ICSI by the study group (ICSI-MII, ICSI-MIX, ICSI-IVMC)
| Overall (n = 4022) | ICSI-MII (n = 2580) | ICSI-MIX (n = 1400) | ICSI-IVMC (n = 42) | p-value1 | |
|---|---|---|---|---|---|
| Age (years); mean (SD) | 37.7 (4.8) | 37.8 (4.8) | 37.2 (4.7)* | 38.8 (5.3) | 0.001 |
| BMI (kg/m2); mean (SD) | 23.6 (4.1) | 23.6 (4.1) | 23.7 (4.1) | 25.9 (5.5)* | 0.001 |
| Oocyte recovered at OPU; mean (SD) | |||||
| COC | 9.2 (6.0) | 8.4 (5.9) | 10.9 (5.8)* | 4.6 (3.8)* | < 0.001 |
| MII | 6.4 (4.4) | 6.4 (4.5) | 6.6 (4.1) | 0* | < 0.001 |
| MI | 1.1 (1.6) | 0.4 (0.9) | 2.3 (1.8)* | 3.0 (2.1)* | < 0.001 |
| GV | 1.1 (1.8) | 0.9 (1.6) | 1.4 (2.0)* | 0.4 (0.9) | < 0.001 |
| IVMC | 0.6 (1.0) | 0 | 1.6 (1.0)* | 2.2 (1.3)* | < 0.001 |
| Timeframe between OPU and ICSI (h); mean (SD) | 4.6 (1.8) | 4.2 (1.5) | 5.3 (2.1)* | 6.6 (1.7)* | < 0.001 |
COC cumulus-oophorus complex, GV germinal vesicle, ICSI = intracytoplasmic injection, IVMC in vitro meiotic completion, MI metaphase I oocytes (immature post-GVBD oocytes), MII metaphase II oocytes (mature oocytes), OPU oocytes pick-up, SD standard deviation
*Statistically siginificant difference after pairwise comparison with Bonferroni’s correction between this group and ICSI-MII
1One-way ANOVA or Pearson’s Chi2 test, as appropriate