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. 2019 Sep 6;14(9):e0217668. doi: 10.1371/journal.pone.0217668

Fig 3. K-TOPE predicted four epitopes in the Rhinovirus A genome polyprotein.

Fig 3

(A) K-TOPE was applied to the Rhinovirus A genome polyprotein (P07210) for 250 specimens. Histograms for all specimens are shown as rows in a heat map. The specimens have been clustered such that specimens that bind the same epitopes are adjacent. Regions that contain epitopes are outlined by dotted lines. (B) A table of the percentage of the population that bound each epitope. (C) The region from positions 570–620 is divided into 3 sections that correspond to distinct epitopes. These epitopes are consensus epitopes which were present in >30% of the 250 specimens. (D) Bar graph showing membership in different epitope groups. For example, a specimen that binds epitopes 2 and 3 will belong to epitope group “2+3”. In this population, 87% of the specimens bound at least one of the consensus epitopes. The sequences of the epitopes were 1: QNPVENYI, 2: DSVLEVLVVPN, 3: APALDAAETGHT, and 4: NHTHPGEQG.