Fig 9. rAAS27 blocks formalin- and compound 48/80-induced acute inflammation in vivo.

(A) Rat paw edema induced by intradermal injection of 100 μL of formalin (0.03%) in saline (circles), or co-injected with 25 μg of rAAS27 (squares), or 100 μL of rAAS27 only (triangles). (B) Rat paw edema induced by intradermal injection of 100 μL of compound 48/80 (1 μg) in saline (circles), or co-injected with 25 μg of rAAS27 (squares), or 100 μL of rAAS27 only (triangles). Edema formation was estimated using a digital pletismometer before injection of the agonist at different intervals. Posterior paws from 5 animals were used for each data point. Unpaired t-test was used for statics analysis and p ≤0.05 was considered statistically significant.