Table 3.
Risk ratios for ischemic placental disease and ischemic placental disease components in donor in vitro fertilization (IVF) and autologous IVF groups compared with non-IVF group
| Donor IVF (n = 262) |
Autologous IVF (n = 3501) |
Non-IVF (n = 65321) |
|
|---|---|---|---|
| Small for gestational age < 10th percentile | |||
| Ischemic placental disease or IUFD | 95 (36.3) | 963 (27.5) | 8773 (13.4) |
| Crude RR (95% CI) | 2.7 (2.2–3.2) | 2.0 (1.9–2.2) | 1.0 (reference) |
| Adjusted RR (95% CI)a | 2.9 (2.5–3.4) | 2.0 (1.9–2.1) | 1.0 (reference) |
| Preeclampsia | 47 (17.9) | 322 (9.2) | 2354 (3.6) |
| Crude RR (95% CI) | 5.0 (3.8–6.5) | 2.6 (2.3–2.9) | 1.0 (reference) |
| Adjusted RR (95% CI)b | 3.8 (2.8–5.0) | 2.2 (2.0–2.5) | 1.0 (reference) |
| Placental abruption | 12 (4.6) | 111 (3.2) | 843 (1.3) |
| Crude RR (95% CI) | 3.5 (2.0–6.2) | 2.5 (2.0–3.3) | 1.0 (reference) |
| Adjusted RR (95% CI)c | 3.8 (2.1–6.7) | 2.5 (2.1–3.1) | 1.0 (reference) |
| Small for gestational age | 58 (22.1) | 669 (19.1) | 6207 (9.5) |
| Crude RR (95% CI) | 2.3 (1.9–3.0) | 2.0 (1.9–2.2) | 1.0 (reference) |
| Adjusted RR (95% CI)a | 2.7 (2.1–3.4) | 2.0 (1.9–2.2) | 1.0 (reference) |
| Small for gestational age < 3rd percentile | |||
| Ischemic placental disease or IUFD | 70 (26.7) | 581 (16.6) | 4452 (6.8) |
| Crude RR (95% CI) | 3.9 (3.2–4.8) | 2.4 (2.2–2.6) | 1.0 (reference) |
| Adjusted RR (95% CI)b | 3.4 (2.7–4.2) | 2.3 (2.1–2.5) | 1.0 (reference) |
| Small for gestational age | 19 (7.3) | 189 (5.4) | 1433 (2.2) |
| Crude RR (95% CI) | 3.3 (2.1–5.1) | 2.5 (2.1–2.9) | 1.0 (reference) |
| Adjusted RR (95% CI)b | 3.4 (2.2–5.4) | 2.5 (2.1–2.9) | 1.0 (reference) |
IVF, in vitro fertilization; IUFD, intrauterine fetal demise. Data presented as n (%) or risk ratio (RR) and 95% confidence interval (CI)
aAdjusted for age and parity
bAdjusted for age, parity, and marital status
cAdjusted for age