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. 2019 Jun 27;18(9):1807–1823. doi: 10.1074/mcp.RA119.001612

Fig. 5.

Fig. 5.

TGM4 diagnostic performance. Performance of TGM4 protein as measured by an in-house ELISA in all 228 SP samples (A) and 80 blood serum samples (B). For comparison, age and serum PSA provided AUCs 0.60 ([95% CI 0.53–0.68]; MWU p = 0.0105) and 0.56 ([0.48–0.63]; p = 0.18) in the same cohorts of patients. C, TGM4 performance in three phases (qualification in SP by SRM, independent verification in SP by SRM, and independent verification in SP by ELISA) for the most clinically relevant patient groups (serum PSA ≥4 ng/ml and age ≥50 years old). As measured by ELISA, TGM4 provided AUC = 0.66 to predict PCa on biopsy and outperformed age and serum PSA. Concentration cut-off >1.74 μg/ml revealed 92% specificity at 31% sensitivity, and substantially increased specificity of serum PSA ≥4 ng/ml to detect PCa.