. 2019 Apr 11;32(9):1244–1256. doi: 10.1038/s41379-019-0270-4

Table 2.

Hazard ratios and 95% confidence intervals for univariable and multivariable associations between IHC4-score and breast cancer subtypes (luminal B-like vs. A-like) with 10-year breast cancer-specific survival among women in the Polish and SEARCH study populations and in both studies combined

	Polish study			SEARCH study			Combined
Parameter	Hazard ratio	P-value	LR χ²	Hazard ratio	P-value	LR χ²	Hazard ratio	P-value	LR χ²
Univariable analysis
Subtype (luminal B-like vs. A-like)	1.75 (0.88–3.48)	0.11	2.8	1.65 (1.23–2.21)	0.001	10.9	1.64 (1.25–2.14)	<0.001	23.4
IHC4-score/1 standard deviation	1.54 (1.27–1.81)	<0.001	13.7	1.28 (1.15–1.41)	<0.001	18.2	1.32 (1.20–1.44)	<0.001	40.1
C-score /1 standard deviation	1.73 (1.45–2.02)	<0.001	23.9	1.79 (1.67–1.92)	<0.001	137.9	1.78 (1.67–1.90)	<0.001	168.2
PREDICT-score/1 standard deviation	2.21 (1.67–2.93)	<0.001	27.9	2.41 (2.10–2.77)	<0.001	144.7	2.34 (2.07–2.65)	<0.001	178.5
Multivariable analysis^a
IHC4-score/1 standard deviation	1.46 (1.18–1.74)	0.001	9.8	1.25 (1.11–1.39)	<0.001	12.0	1.29 (1.16–1.42)	<0.001	19.1
C-score/1 standard deviation	1.62 (1.31–1.93)	<0.001	14.5	1.78 (1.65–1.91)	<0.001	129.1	1.75 (1.63–1.87)	<0.001	140.1
Multivariable analysis^b
IHC4-score/1 standard deviation	1.46 (1.17–1.74)	0.002	9.2	1.19 (1.05–1.33)	0.007	7.0	1.24 (1.11–1.37)	<0.001	12.5
PREDICT-score/1 standard deviation	1.91 (1.43–2.56)	<0.001	17.1	2.40 (2.09–2.77)	<0.001	135.7	2.26 (1.99–2.56)	<0.001	147.1
Multivariable analysis^c
Subtype (luminal B-like vs. A-like)	1.24 (0.58–2.62)	0.58	0.3	1.51 (1.08–2.12)	0.02	5.7	1.38 (1.02–1.88)	0.04	4.3
PREDICT-score/1 standard deviation	1.94 (1.44–2.76)	<0.001	17.6	2.48 (2.13–2.88)	<0.001	125.1	2.30 (2.01–2.63)	<0.001	136.5
Multivariable (luminal A-like tumors only)
IHC4-score/1 standard deviation	1.29 (0.69–1.90)	0.34	0.9	1.15 (0.93–1.40)	0.17	1.9	1.20 (0.98–1.43)	0.07	3.1
PREDICT-score/1 standard deviation	1.32 (0.57–3.07)	0.51	3.7	2.33 (1.87–2.90)	<0.001	52.1	2.14 (1.74–2.64)	<0.001	46.1
Multivariable (luminal B-like tumors only)
IHC4-score/1 standard deviation	1.48 (1.14–1.82)	0.006	6.9	1.14 (0.92–1.36)	0.20	1.6	1.22 (1.03–1.41)	0.01	5.3
PREDICT-score/1 standard deviation	2.21 (1.56–3.12)	<0.001	18.5	2.59 (2.06–3.26)	<0.001	65.7	2.36 (1.96–2.84)	<0.001	80.4

^aHazard ratio was mutually adjusted for IHC4-score, C-score, age, treatment, and, in the combined model, study

^bHazard ratio was mutually adjusted for IHC4-score, age, PREDICT-score (which combines information on lymph-nodal involvement, histologic grade, patient age, tumor size, and mode of detection—because we did not have data on mode of detection, this was not computed), treatment and, in the combined model, study

^cHazard ratio was mutually adjusted for subtype, age, PREDICT-score, treatment and, in the combined model, study. LRχ² = likelihood ratio chi-square