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. Author manuscript; available in PMC: 2019 Sep 11.
Published in final edited form as: Chem Rev. 2019 Mar 6;119(17):9950–9970. doi: 10.1021/acs.chemrev.8b00660

Figure 2.

Figure 2.

Representative biological aptamers. (A) DARPin scaffold, with constant N- and C-terminal modules, and 3 copies of the ankyrin repeat module, with the sequence of that module shown below. The library is built through substitutions at the residues indicated by the red ‘x’. (B) The Adhiron affimer scaffold, which was derived from a large number of plant cystatin sequences. The library is built through substitutions at the purple-colored loops, which are expanded beyond the 7 indicated residues. The figures in A and B are from Tamaskovic, R. et al., Methods … 2012, 503, 101 (ref. 172) and Tiede, C. et al., Elife 2017, 6, e24903 (ref. 44), respectively).