Table 2.
Effect of Exercise Versus Usual Care on FACT Measures at Baseline and Changes at 6 months and 12 months.
| Outcome | Usual Care | Exercise | Exercise Effect | P value | |
|---|---|---|---|---|---|
| FACT-G | |||||
| Physical well-being | Baseline | 21.0 (4.5) | 21.8 (4.2) | 0.31 | |
| 6-month change | 0.6(−0.4, 1.5) | 1.7( 0.8, 2.5) | 1.1(−0.0, 2.2) | 0.05 | |
| 12-month change | −0.1(−1.2, 1.0) | 2.4( 1.4, 3.5) | 2.5( 1.0, 4.0) | 0.001 | |
| Social/Family well-being | Baseline | 21.4 (5.0) | 21.5 (5.4) | 0.89 | |
| 6-month change | −0.7(−1.8, 0.3) | 0.5(−0.5, 1.5) | 1.2(−0.2, 2.7) | 0.09 | |
| 12-month change | 0.4(−0.7, 1.6) | 1.4( 0.3, 2.5) | 1.0(−0.6, 2.5) | 0.23 | |
| Emotional well-being | Baseline | 19.2 (4.4) | 19.3 (4.0) | 0.90 | |
| 6-month change | 0.9( 0.1, 1.7) | 1.1( 0.3, 1.8) | 0.2(−0.8, 1.1) | 0.69 | |
| 12-month change | 0.7(−0.1, 1.6) | 1.7( 0.9, 2.4) | 0.9(−0.1, 2.0) | 0.08 | |
| Functional well-being | Baseline | 20.4 (4.9) | 20.3 (5.2) | 0.92 | |
| 6-month change | 0.9(−0.3, 2.1) | 1.1( 0.0, 2.2) | 0.2(−1.3, 1.8) | 0.77 | |
| 12-month change | 0.1(−1.1, 1.3) | 2.6( 1.5, 3.7) | 2.5( 0.9, 4.1) | 0.002 | |
| FACT-G | Baseline | 82.0 (14.8) | 82.9 (15.1) | 0.73 | |
| 6-month change | 1.5(−1.4, 4.5) | 4.3( 1.6, 7.0) | 2.7(−1.0, 6.5) | 0.153 | |
| 12-month change | 1.2(−2.0, 4.4) | 8.0( 5.1, 11.0) | 6.8( 2.6, 11.0) | 0.002 | |
| FACT-B | |||||
| Breast cancer subscale | Baseline | 18.3 (4.8) | 19.2 (4.7) | 0.26 | |
| 6-month change | 0.7(−0.2, 1.5) | 1.1( 0.3, 2.0) | 0.5(−0.6, 1.6) | 0.39 | |
| 12-month change | 0.7(−0.2, 1.7) | 2.2( 1.3, 3.1) | 1.4( 0.1, 2.7) | 0.03 | |
| FACT-B | Baseline | 100.2 (18.0) | 102.2 (18.7) | 0.57 | |
| 6-month change | 2.2(−1.2, 5.6) | 5.4( 2.3, 8.5) | 3.2(−1.1, 7.6) | 0.14 | |
| 12-month change | 2.0(−1.8, 5.7) | 10.2( 6.7, 13.6) | 8.2( 3.3, 13.2) | 0.001 | |
| FACT-ES | |||||
| Endocrine subscale | Baseline | 54.9 (9.8) | 56.5 (10.1) | 0.38 | |
| 6-month change | 1.3(−0.6, 3.3) | 2.0( 0.2, 3.8) | 0.6(−1.9, 3.2) | 0.62 | |
| 12-month change | 1.7(−0.2, 3.6) | 5.5( 3.7, 7.2) | 3.8( 1.3, 6.2) | 0.003 | |
| FACT-B-ES | |||||
| FACT-B-ES | Baseline | 155.2 (25.5) | 158.7 (26.8) | 0.46 | |
| 6-month change | 3.6(−1.1, 8.2) | 7.4( 3.2, 11.7) | 3.9(−1.9, 9.7) | 0.19 | |
| 12-month change | 3.7(−1.3, 8.7) | 15.6(11.0, 20.2) | 11.9( 5.3, 18.5) | 0.0005 | |
| FACIT-FATIGUE | |||||
| Fatigue subscale | Baseline | 36.2 (10.8) | 37.9 (10.6) | 0.39 | |
| 6-month change | 0.5(−1.7, 2.8) | 3.8( 1.7, 5.9) | 3.3( 0.4, 6.1) | 0.03 | |
| 12-month change | 0.5(−1.6, 2.6) | 5.7( 3.8, 7.7) | 5.2( 2.5, 8.0) | 0.0003 | |
Baseline scores are presented as means (standard deviation). 6-month or 12-month change are presented as least square means and 95% confidence interval from mixed model analysis adjusting for baseline score and age.
At 6 months, 47 controls (78.3%) and 58 (95.1%) exercisers completed the QOL assessment. At 12 months, 38 (79.2%) controls and 45 (93.8%) exercisers completed the QOL assessment. Due to a funding cut, 25 women were only enrolled for a 6-month study rather than 12 months and were therefore not included in the 12-month analyses.