Table 4.

Neuroimaging features selected with frequency > 80% based on 1000 repetitions of the nested cross-validation along with the direction (positive/negative) of the most frequent sign of the regression coefficient have been reported. For each neuropsychological test, the score interpretation has been also indicated.

Neuropsychological test	Cognitive scores interpretation (worst to best performance)	Relevant features
MoCA	Low to high values	WM FD (+), WM lesions load (−)
SDMT	Low to high values	WM FD (+), GM volume (+), GM mfs (−)
TMT-A	High to low values	Cerebral microbleeds (+), Lacunar infarcts (−), WM FD (−), GM FD (−),GM mfs (+), GM Mfs (−), WM lesions load (+), WM Mfs (−)

MoCA, montreal cognitive assessment; SDMT, symbol digit modalities test; TMT-A, trail making test - part A.

(+): a positive direction of the regression coefficient sign indicating a direct association.

(−): a negative direction of the regression coefficient sign indicating an inverse association.