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. 2019 Sep 6;9:12848. doi: 10.1038/s41598-019-49262-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of CeO₂NPs on hepatic histology. (A) Hematoxylin & Eosin, CD68 and Sirius Red staining of representative liver sections obtained from control rats, MCDD rats receiving vehicle and MCDD rats receiving CeO₂NPs. Original magnification 100x for H&E and Sirius Red, and 200x for CD68. (B) Quantitative measurement of fat content (%) in MCDD animals. ***p < 0.001 compared to vehicle group. Unpaired Student’s t test. (C) Quantitative measurement of CD68 positive cells/field in all animals. ***p < 0.01 compared to control group. One way ANOVA with Turkey’s multiple comparison test. Results are shown as mean ± SEM.