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. 2019 Sep 6;9:12848. doi: 10.1038/s41598-019-49262-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A volcano plot showing the differentially expressed genes related to oxidative stress in a pair-wise comparison of vehicle- and CeO₂NP-treated MCDD rats. Significances was set at a p value based on a Student’s t-test of 0.05 [−log10 (p-value) ≥ 1.30]. The biological cut-off was set at a fold regulation of ±2 fold [−1 ≥ log2 (FC of CeO₂NPs/Vehicle) ≥ 1]. The top 6 differentially expressed genes are labeled with their corresponding gene ID. The different color codes used represent biologically but not statistically significant genes (grey) and both biologically and statistically significant down-regulated (green) genes, in CeO₂NP treated rats.