Table 4.
Content of PE-derived FAs in the liver of control and MCDD non-treated (vehicle) and treated (CeO2NPs) rats (nmol/mg tissue).
| Fatty acid | Control (n = 4) | MCDD rats | |
|---|---|---|---|
| Vehicle (n = 8) | CeO2NPs (n = 7) | ||
| C10:0 | ND | ND | ND |
| C11:0 | ND | ND | ND |
| C12:0 | ND | ND | ND |
| C13:0 | ND | ND | ND |
| C14:0 | 0.09 ± 0.02 | 0.09 ± 0.03 | 0.04 ± 0.00* |
| C14:1 | ND | ND | ND |
| C15:0 | IS | IS | IS |
| C15:1 | ND | ND | ND |
| C16:0 | 17.57 ± 1.68 | 13.24 ± 0.95* | 12.67 ± 1.07* |
| C16:1 | 0.71 ± 0.18 | 0.22 ± 0.04** | 0.21 ± 0.03** |
| C17:0 | 0.40 ± 0.06 | 0.26 ± 0.018* | 0.26 ± 0.01* |
| C17:1 | 0.10 ± 0.02 | 0.10 ± 0.01 | 0.10 ± 0.01 |
| C18:0 | 11.31 ± 2.29 | 13.19 ± 1.18 | 13.31 ± 1.00 |
| C18:1n9 | 6.37 ± 0.88 | 4.42 ± 0.47 | 4.13 ± 0.35* |
| C18:2n6 | 8.21 ± 1.07 | 4.96 ± 0.53* | 5.06 ± 0.42** |
| C18:3n6 | 0.16 ± 0.031 | 0.18 ± 0.03 | 0.17 ± 0.02 |
| C18:3n3 | 0.38 ± 0.08 | 0.37 ± 0.09 | 0.39 ± 0.07 |
| C19:0 | ND | ND | ND |
| C20:0 | 0.06 ± 0.01 | 0.07 ± 0.01 | 0.06 ± 0.01 |
| C20:1n9 | ND | ND | ND |
| C20:2 | 0.20 ± 0.03 | 0.14 ± 0.02 | 0.16 ± 0.02 |
| C20:3n3 | ND | ND | ND |
| C20:3n6 | 0.69 ± 0.11 | 0.57 ± 0.04 | 0.61 ± 0.04 |
| C20:4n6 | 27.55 ± 2.31 | 15.75 ± 1.11*** | 16.28 ± 1.00*** |
| C20:5n3 | ND | ND | ND |
| C21:0 | ND | ND | ND |
| C22:0 | 0.05 ± 0.01 | 0.04 ± 0.01 | 0.05 ± 0.00 |
| C22:1n9 | ND | ND | ND |
| C22:2 | ND | ND | ND |
| C22:6n3 | 4.81 ± 0.67 | 12.09 ± 1.25 | 7.10 ± 0.97***,†† |
| C23:0 | ND | ND | ND |
| C24:0 | ND | ND | ND |
| C24:1n9 | 0.083 ± 0.026 | 0.081 ± 0.032 | 0.12 ± 0.02 |
| SFA | 29.48 ± 3.94 | 26.89 ± 2.16 | 26.39 ± 2.07 |
| UFA | 49.27 ± 3.48 | 33.89 ± 2.28** | 39.32 ± 2.16* |
| MUFA | 72.65 ± 1.01 | 4.82 ± 0.53* | 4.55 ± 0.36* |
| PUFA | 42.00 ± 3.31 | 29.07 ± 2.09** | 34.76 ± 1.86 |
Values are expressed as mean ± SEM. SFA, saturated fatty acids; UFA, unsaturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids. ND, non-detected peak; IS, internal standard. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control rats; ††p < 0.01 vs. MCDD rats receiving vehicle. Unpaired Student’s t-test and Mann Whitney test when appropriate.