Table 5.
Content of Triglyceride-derived FAs in the liver of control, non-treated (vehicle) and treated (CeO2 NPs) MCDD rats (nmol/mg tissue).
| Fatty acid | Control rats (n = 4) | MCDD rats | |
|---|---|---|---|
| Vehicle (n = 8) | CeO2 NPs (n = 7) | ||
| C10:0 | 1.12 ± 0.71 | 0.52 ± 0.20 | 0.33 ± 0.09 |
| C12:0 | 1.22 ± 0.64 | 0.48 ± 0.13 | 0.34 ± 0.07 |
| C13:0 | 0.24 ± 0.1 | 0.04 ± 0.01 | 0.02 ± 0.0 |
| C14:0 | 3.55 ± 1.99 | 5.32 ± 1.13 | 4.48 ± 0.57 |
| C14:1 | 0.63 ± 0.36 | 0.20 ± 0.12 | 0.08 ± 0.02 |
| C15:0 | 0.77 ± 0.36 | 1.94 ± 0.39 | 1.43 ± 0.16 |
| C16:0 | 58.2 ± 24.5 | 303.4 ± 38.7*** | 220.5 ± 20.1*** |
| C16:1 | 14.5 ± 9.4 | 8.3 ± 1.9 | 6.5 ± 0.8 |
| C17:0 | 0.27 ± 0.12 | 1.73 ± 0.37* | 1.35 ± 0.18 ** |
| C17:1 | 0.46 ± 0.22 | 0.61 ± 0.17 | 0.43 ± 0.05 |
| C18:0 | 3.08 ± 1.28 | 42.0 ± 5.9*** | 34.6 ± 4.1*** |
| C18:1n9 | 44.3 ± 19.5 | 237.6 ± 28.6*** | 161.0 ± 17.8**,† |
| C18:2n6 | 54.8 ± 20.1 | 516.1 ± 66.6*** | 384.1 ± 47.2*** |
| C18:3n6 | 1.2 ± 0.4 | 21.5 ± 4.3** | 19.7 ± 2.5*** |
| C18:3n3 | 4.0 ± 1.7 | 19.7 ± 3.1** | 14.3 ± 2.** |
| C19:0 | IS | IS | IS |
| C20:0 | 0.21 ± 0.11 | 0.61 ± 0.12* | 0.43 ± 0.04 |
| C20:1n9 | 0.51 ± 0.24 | 2.47 ± 0.53* | 1.77 ± 0.19** |
| C20:2 | 0.34 ± 0.20 | 7.27 ± 1.66** | 5.3 ± 0.65*** |
| C20:3n6 | 1.28 ± 0.53 | 19.87 ± 4.81* | 14.57 ± 1.71*** |
| C20:4n6 | 5.2 ± 2.0 | 112. ± 18.8** | 91.8 ± 9.3*** |
| C20:5n3 | 1.2 ± 0.5 | 4.6 ± 0.7*** | 4.6 ± 0.6*** |
| C21:0 | 0.08 ± 0.04 | 0.04 ± 0.00 | 0.03 ± 0.00 |
| C22:0 | 0.19 ± 0.12 | 0.14 ± 0.02 | 0.09 ± 0.01 |
| C22:1n9 | 0.10 ± 0.03 | 0.28 ± 0.05* | 0.19 ± 0.03 |
| C22:2 | 0.30 ± 0.16 | 0.49 ± 0.16 | 0.42 ± 0.07 |
| C22:6n3 | 1.1 ± 0.5 | 14.5 ± 3.8* | 12.9 ± 2.0** |
| C23:0 | 0.07 ± 0.03 | 0.031 ± 0.00 | 0.031 ± 0.00 |
| C24:0 | 0.20 ± 0.15 | 0.08 ± 0.02 | 0.132 ± 0.0 |
| C24:1n9 | 0.18 ± 0.05 | 0.19 ± 0.06 | 0.12 ± 0.02 |
| SFA | 69.3 ± 30.0 | 356.4 ± 45.4*** | 264.8 ± 24.0*** |
| UFA | 130.5 ± 54.3 | 966.6 ± 128.0*** | 718.0 ± 80.7*** |
| MUFA | 60.7 ± 29.6 | 249.8 ± 30.1** | 170.1 ± 17.9**,† |
| PUFA | 69.7 ± 25.2 | 716.8 ± 99.6*** | 547.9 ± 63.9*** |
Values are expressed as mean ± SEM. SFA, saturated fatty acids; UFA, unsaturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids. ND, non-detected peak; IS, internal standard. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control rats; †p < 0.05 vs. MCDD rats receiving vehicle. Unpaired Student’s t-test and Mann Whitney test when appropriate.