Table 6.
Content of CE-derived FAs in the liver of control and MCDD non-treated (vehicle) and treated (CeO2NPs) rats (pmol/mg tissue).
| Fatty acid | Control (n = 4) | MCDD rats | |
|---|---|---|---|
| Vehicle (n = 8) | CeO2NPs (n = 7) | ||
| C10:0 | ND | ND | ND |
| C12:0 | ND | ND | ND |
| C13:0 | ND | ND | ND |
| C14:0 | 24.2 ± 6.0 | 250.3 ± 64.1* | 60.8 ± 9.8*,† |
| C14:1 | 30.5 ± 6.7 | 38.4 ± 6.9 | 73.8 ± 12.9 *,† |
| C15:0 | 11.7 ± 6.6 | 117.5 ± 20.8** | 52.5 ± 7.7**,† |
| C16:0 | 3634.4 ± 630.0 | 16464.0 ± 2863.0* | 8204.5 ± 621.0**,† |
| C16:1 | 98.6 ± 69.5 | 625.7 ± 43.8*** | 503.1 ± 30.7***,† |
| C17:0 | IS | IS | IS |
| C17:1 | 62.7 ± 16.1 | 64.4 ± 8. | 96.371 ± 18.0 |
| C18:0 | 347.8 ± 59.5 | 2503.4 ± 535.0* | 1342.0 ± 169.0** |
| C18:1n9 | 711.9 ± 158.0 | 14427.7 ± 2298.0** | 8602.7 ± 692.0***,† |
| C18:2n6 | 834.2 ± 151.0 | 26354.5 ± 3951.0** | 16129.1 ± 1306.0***,†*,† |
| C18:3n6 | 43.1 ± 21.1 | 698.9 ± 153.0* | 292.116 ± 17.2**,† |
| C18:3n3 | 77.5 ± 16.5 | 1127.9 ± 159.0** | 828.6 ± 64.1*** |
| C19:0 | ND | ND | ND |
| C20:0 | 7.8 ± 2.4 | 59.8 ± 14.1* | 38.0 ± 8.9* |
| C20:1n9 | 16.8 ± 7.6 | 159.6 ± 50* | 46. ± 10.2* |
| C20:2 | 17.6 ± 6.5 | 277.6 ± 93.8** | 87.4 ± 25.9** |
| C20:3n6 | 44.8 ± 12.5 | 653.4 ± 143.0* | 411.600 ± 60.8** |
| C20:4n6 | 635.9 ± 114.0 | 8533.6 ± 1273.0** | 9311.5 ± 831.0*** |
| C20:5n3 | ND | ND | ND |
| C21:0 | 5.4 ± 2.1 | 8.3 ± 0.7 | 12.6 ± 4.3 |
| C22:0 | 7.3 ± 2.1 | 24.2 ± 3.3** | 24.9 ± 5.2* |
| C22:1n9 | 49.2 ± 8.6 | 112.6 ± 27.1 | 133.6 ± 18.6* |
| C22:2 | 33.2 ± 11.7 | 69.3 ± 13.7 | 83.114 ± 17.6 |
| C22:6n3 | 73.1 ± 21.4 | 557.8 ± 46.0*** | 997.4 ± 75.1***,††† |
| C23:0 | 5.3 ± 1.8 | 6.6 ± 1.1 | 9.4 ± 2.4 |
| C24:0 | 9.1 ± 3.4 | 31.2 ± 5.3* | 35.6 ± 7.1* |
| C24:1n9 | ND | ND | ND |
| SFA | 3966.4 ± 740.0 | 19465.8 ± 3471.0* | 9780.7 ± 756.3***,† |
| UFA | 2705.1 ± 520.1 | 53701.3 ± 6375.0*** | 37597.2 ± 2530.0***,† |
| MUFA | 945.2 ± 228.5 | 15428.0 ± 2346.0** | 9456.1 ± 697.8***,† |
| PUFA | 1759.8 ± 323.2 | 38273.3 ± 4237.0*** | 28141.1 ± 2140.0*** |
Values are expressed as mean ± SEM. SFA, saturated fatty acids; UFA, unsaturated fatty acids; MUFA, monounsaturated fatty acids; PUFA, polyunsaturated fatty acids. ND, non-detected peak; IS, internal standard. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control rats; †p < 0.05, †††p < 0.001 vs. MCDD rats receiving vehicle. Unpaired Student’s t-test and Mann Whitney test when appropriate.