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. 2019 Sep 6;10:4052. doi: 10.1038/s41467-019-11933-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — SD reshapes the metabolic transitions between hunger and satiety in fly heads. a The effects of short, (2 days, SD2), medium (5 days, SD5), and longer term (7 days, SD7) consumption of a high sugar diet (SD) compared to a control diet (CD) on the magnitude of the metabolite differences between the fasted and refed state on each diet. The size of the bars is proportional to the number of compounds in each metabolite category on the left. In blue are metabolites that were significantly different between fasted and refed flies in each condition (CD, SD2, SD5, and SD7 by Welch’s t-test, FDR < 0.1), and in gray metabolites that were not. b, c Projection onto the two most explanatory principal components for compound levels from b refed and c fasted heads of flies on CD (green) and fed a SD (purple shades) for 2 days (SD2), 5 days (SD5), or 7 days (SD7). The solid lines represent the 95% confidence interval, and percent explained variance is listed in parentheses. d, e Principal component loadings for the d refed and e fasted heads of flies fed a CD, or SD2, SD5, or SD7. Labels represent characteristic compounds. Source data are provided as a Source Data file