Fig. 3.

Timing of mutations in six mouse pedigrees. a Validated de novo mutations in six mouse pedigrees. Offspring are shown vertically, and DNMs are shown horizontally, coloured according to temporal strata. Early embryonic DNMs are shaded according to the parental origin (grey/orange). Late post-PGC and VEE mutations are only observed in one individual and are listed in Supplementary Table 1 and Supplementary Data 1. b The number of DNMs assigned to the paternal or maternal haplotype (‘Methods’) in each temporal strata, with the total contribution of mutations in each strata to the overall rate shown at the bottom of the graph