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. 2019 Sep 6;10:4053. doi: 10.1038/s41467-019-12023-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Mutational spectra and paternal age effect of DNMs in mice. a Comparison of mutational spectra in mice and humans using a catalogue of compiled DNMs in humans³. Error bars are 95% confidence intervals. Stars show significance (p < 0.05) after correction for multiple testing. The mouse data were derived from DNMs in 40 offspring from six pedigrees and the human data from 6570 DNMs from 109 trios³. b Comparison of mutational spectra in VEE+EE mutations compared to peri-PGC+late post-PGC mutations in mice. Effect of parental age on number of DNMs in individuals before (c) and after (d) removal of VEE mutations arising in offspring. The size of the plotting symbol indicates the number of individuals sharing the same number of mutations. p Values indicate the significance of the regression coefficients. The grey shading indicates the confidence limits on the regression. The mouse DNMs were derived from 40 offspring in six pedigrees