Table 1.

Autosomal SNV germline mutation rates per generation, per year and per cell division in humans and mice

	Human	Mouse
Mutations per genome per generation	~71	~20
Mutation rate per genome per generation	1.22 × 10−8 [1.14 × 10−8–1.31 × 10−8]	0.39 × 10−8 [0.37 × 10−8–0.42 × 10−8]
Mutation rate per year	4.08 × 10−10 [3.80 × 10−10–4.35 × 10−10]	53 × 10−10 [49 × 10−10–56 × 10−10]
Average mutation rate per cell division	5.67 × 10−11 [5.28 × 10−11–6.05 × 10−11]	9.07 × 10−11 [8.41 × 10−11–9.69 × 10−11]

95% confidence intervals calculated assuming Poisson variance around the mean number of mutations (‘Methods’). Rate per cell division are calculated assuming that mouse and human generation times are 9 months and 30 years, respectively, and the numbers of cell divisions delineated in ref. ⁶. Estimates of mouse mutation rates per year are highly dependent on estimates of average generation time.