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. 2019 Sep 6;10:4028. doi: 10.1038/s41467-019-12021-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The topology of signal-processing networks as perceived from transcription factor-DNA interactions (left column) is contrasted with the actual behavior of these networks (right column). The top row illustrates an example of crosstalk due to a hidden interaction between the inputs and the network. The bottom row illustrates how crosstalk between inputs and the network can be buffered by to crosstalk-compensating circuits