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. 2019 Sep 6;9:12827. doi: 10.1038/s41598-019-49289-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phlda3 induction under ER stress is downstream of XBP1. 4-Hydroxytamoxifen-treated control (C) and Xbp1^flox/flox-Pdx1-Cre^ER (Xbp1^f/f) mouse islets (n = 7 experiments) and MIN6 cells transfected with either control siRNA (si-C), siRNA against Xbp1 (siXbp1) or siRNA against Ddit3 (siDdit3) (n = 9–12 experiments) were cultured in the absence (white bars) or presence (black bars) of cytokines (24 h) or palmitate (48 h). Changes in the mRNA levels of Phlda3 in cytokine-treated MIN6 cells (a) and primary islets (b). Changes in the mRNA levels of Phlda3 in palmitate-treated MIN6 cells (c). **p < 0.01, ***p < 0.001, ****p < 0.0001 vs untreated. ^#p < 0.05, ^##p < 0.01 vs control siRNA or control islets.