Table 5.

Calibrated synergy values for parameter S and approximated combination index values for the different combination therapy experiments.

Regimen	Paclitaxel 25 nM, Trastuzumab 25 μg/mL		Paclitaxel 100 nM, Trastuzumab 25 μg/mL
	S	Combination Index	S	Combination Index
Paclitaxel prior to trastuzumab	0.09	0.75	0.71	[0.7, 0.9]
Paclitaxel and trastuzumab applied simultaneously	0.13	0.55	1.22	<0.7
Trastuzumab prior to paclitaxel	1.47	<0.55	1.24	<0.7