Figure 2.

Representative Brain MR Images of the DLL1 Cohort

(A and B) T1-midsagittal (A) and T2-axial (B) images of I6 showing severe hydrocephalus with a thin/stretched corpus callosum, thin brainstem, small cerebellum, and compression of the overlying cortex.

(C and D) T1-midsagittal (C) and T2-axial (D) images of I7 showing a mildly short and thick corpus callosum, and subtle areas of cortical dysplasia.

(E and F) T1-midsagittal (E) and T2-axial (F) images of I8 showing a mildly dysplastic corpus callosum, mild cortical dysplasia, and mild ventriculomegaly.

(G and H) T1-midsagittal (G) and T2-axial (H) images of I9 showing relatively large brain size with a prominent forehead, mildly dysplastic corpus callosum, and mildly dilated ventricles.

(I and J) T1-axial images of I12 showing PVNH (red arrowhead, I) with mild ventriculomegaly.

(K and L) T1-midsagittal (K) and T2-axial (L) images of I14 showing a mildly short and dysplastic corpus callosum, mildly small pons, and subtle cortical dysplasia.

(M and N) Prenatal T2 sagittal (M) and axial (N) images of I1 showing ventriculomegaly, with no good mid-sagittal views.

(O and P) Prenatal T2 sagittal (O) and axial (P) images of I13 showing asymmetric ventriculomegaly.