Table 2.

Associations Between Putative Susceptibility Gene Expression Levels and Mutational Signatures for Five Cancer Types (Bonferroni-Corrected p < 0.05)

Gene	Beta	P	Bonferroni-Corrected P
Breast Cancer (Signature 3)∗
FAM72B	0.54	<2.20 × 10−16	5.46 × 10−13
PRC1	0.55	<2.20 × 10−16	5.46 × 10−13
NEK10	−0.48	2.22 × 10−16	6.06 × 10−13
NTN4	−0.39	1.89 × 10−12	5.16 × 10−9
APOBEC3B	0.44	1.92 × 10−11	5.24 × 10−8
RCCD1	0.38	1.46 × 10−10	3.99 × 10−7
EIF2S2	0.37	1.58 × 10−10	4.31 × 10−7
DCLRE1B	0.35	2.34 × 10−10	6.39 × 10−7
DYNLRB2	−0.37	2.93 × 10−10	8.00 × 10−7
ESR1	−0.38	1.28 × 10−9	3.49 × 10−6
ATP6AP1L	−0.34	4.59 × 10−9	1.25 × 10−5
PDZK1	−0.30	2.52 × 10−8	6.88 × 10−5
ITPR1	−0.33	1.83 × 10−7	5.00 × 10−4
FGF10	−0.32	1.93 × 10−7	5.27 × 10−4
TOX3	−0.28	6.31 × 10−7	1.72 × 10−3
APOBEC3A	0.26	2.35 × 10−6	6.42 × 10−3
GATAD2A	0.29	6.35 × 10−6	0.017
POLR2L	−0.25	7.58 × 10−6	0.021
SLC4A7	−0.26	7.61 × 10−6	0.021
Breast Cancer (Signature 13)
APOBEC3A	0.48	2.84 × 10−14	7.75 × 10−11
DYNLRB2	−0.41	2.26 × 10−11	6.17 × 10−8
ATP6AP1L	−0.39	1.73 × 10−10	4.72 × 10−7
ESR1	−0.37	1.19 × 10−9	3.25 × 10−6
AMFR	−0.35	8.97 × 10−9	2.45 × 10−5
APOBEC3B	0.40	1.24 × 10−8	3.39 × 10−5
PDZK1	−0.34	1.85 × 10−8	5.05 × 10−5
WNT3	−0.34	3.62 × 10−8	9.88 × 10−5
NEK10	−0.32	1.10 × 10−7	3.00 × 10−4
EIF2S2	0.33	1.59 × 10−7	4.34 × 10−4
MRPS30	−0.31	1.71 × 10−7	4.67 × 10−4
PTPN22	0.32	3.82 × 10−7	1.04 × 10−3
PRC1	0.33	1.35 × 10−6	3.69 × 10−3
FAM72B	0.32	2.96 × 10−6	8.08 × 10−3
CTSW	0.28	5.56 × 10−6	0.015
FGF10	−0.28	8.95 × 10−6	0.024
Breast Cancer (Signature 1)
ATP6AP1L	0.05	3.05 × 10−9	8.33 × 10−6
DYNLRB2	0.04	4.84 × 10−7	1.32 × 10−3
ESR1	0.04	7.63 × 10−7	2.08 × 10−3
Breast Cancer (Signature 2)
WNT3	−0.29	7.48 × 10−8	2.04 × 10−4
Breast Cancer (Signature 16)
NTN4	0.60	1.26 × 10−6	3.44 × 10−3
Colorectal Cancer (Signature 1)
SHROOM2	0.09	3.60 × 10−9	2.38 × 10−6
GPR143	0.09	4.07 × 10−9	2.69 × 10−6
MICB	−0.09	6.26 × 10−9	4.13 × 10−6
A1CF	0.08	1.18 × 10−5	7.80 × 10−3
Colorectal Cancer (Signature 26)
A1CF	−1.39	4.12 × 10−5	0.027
SHROOM2	−1.12	4.77 × 10−5	0.032
Colorectal Cancer (Signature 6)
GPR143	−0.47	2.05 × 10−7	1.35 × 10−4
A1CF	−0.52	2.75 × 10−7	1.81 × 10−4
SHROOM2	−0.42	1.02 × 10−6	6.73 × 10−4
Lung Adenocarcinoma (Signature 4)
TP63	−0.23495	1.94 × 10−5	2.56 × 10−2
Prostate Cancer (Signature 1)
TBX1	0.07	7.18 × 10−8	3.43 × 10−4
MYO6	0.07	2.68 × 10−6	1.28 × 10−2
Melanoma (Signature 20)
CDK10	−0.40	1.09 × 10−6	4.85 × 10−4
Melanoma (Signature 4)
CDK10	−0.31	1.43 × 10−5	6.36 × 10−3
Melanoma (Signature 25)
CDK10	0.72	8.92 × 10−5	0.040
Melanoma (Signature 23)
UQCC	0.32	7.77 × 10−5	0.035

^∗The mutational signatures for each cancer type were derived from TCGA samples.