Figure 1.

BBD inhibited cell growth in a dose-dependent manner in A549 and A549DDP cells. A. IC50 value of cisplatin was determined by CCK8 assay. B. Cell viability after BBD treatment for 24 hours or 48 hours was determined through CCK8 assay. C. Cells were incubated in the same concentrations of BBD for similar 24 hours, cell viability was detected and compared. D. Photographs of crystal violet-stained colonies of BBD-treated both cells growing in 6-well plates for 12-14 days after infection, and the number of cells in each colony was counted. *, P < 0.05; **, P < 0.01; ***, P < 0.001.