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BBD potentiated the chemosensitivity of cisplatin in A549 and A549DDP. (A) IC50 value of cisplatin with or without BBD-pretreatment. (B) Wound healing assay exhibited the migration ability of BBD + DDP treated cells, compared with DDP alone group. (C) Transwell assay revealed the invasion ability of BBD + DDP treated cells, compared with DDP alone group. qRT-PCR assay (D) and Western blot assay (E) determined the expression of MDR1. *, P < 0.05; **, P < 0.01.
