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. 2019 Aug 15;11(8):4957–4966.

Figure 2.

Figure 2

Overexpression of miR-876-3p inhibits glioma cell proliferation. A. The expression level of miR-876-3p in U251 and T98 cells was analyzed by qRT-PCR after transfection. Data were expressed as the mean ± SEM from three independent experiments. *P < 0.05. B. Overexpression of miR-876-3p on the growth of U251 and T98 cells was examined by CCK8 assays. Data were expressed as the mean ± SEM from three independent experiments. *P < 0.05. C and D. Cell viability of miR-876-3p was evaluated using the colony formation assay. Data were expressed as the mean ± SEM from three independent experiments. *P < 0.05. E-G. Overexpression of miR-876-3p effect on cell cycle distribution of U251 and T98 cells. Data were expressed as the mean ± SEM from three independent experiments. *P < 0.05. H. Western blot analysis indicated the regulation of the cell-cycle-regulatory proteins CDK2, CDK4, and CCND1 protein levels in U251 and T98 cells after stable transfection with miR-876-3p and miR-NC. Actin was used as control.