Figure 4.

Irradiation induces RIOM in Lgr5-lacZ transgenic mice. A. Schematic illustration of setup of head-only radiation for mice. B. Representative pictures of tongues stained with toluidine blue (TB) after various dose of IR. C. Histological analysis of the tongues collected from mice at day 10 after IR, Scale bar 200 μm. D. Mean ulcer size percentage to the total epithelialized upper surface of the tongue. E. Quantification of the posterior epithelium height. Data presented as the mean ± SD (n=6). **P<0.01, ***P<0.001 vs. 0 Gy group.