Figure 5.

NAM suppresses the histological signs of oral mucositis induced by single dose irradiation. A. Single dose radiation and drug treatment scheme for mice. A single dose of Nicotinamide (1000 mg/kg, NAM) or PBS administered 24 h after 15 Gy IR. B. Representative pictures of tongues stained with TB and its histological analysis (right panels, HE stained), from control mice (non-irradiated, NR), and irradiated mice on day 10 post IR, after they received vehicle (PBS) or NAM. Scale bar 200 μm. C. Mean ulcer size percentage to the total epithelialized upper surface of the tongue. D. Quantification of the posterior epithelium height. Data presented as the mean ± SD (n=8), *P<0.05, ***P<0.001.