Figure 6.

NAM suppresses the histological signs of oral mucositis induced by fractionated dose irradiation. A. Fractioned radiation and drug treatment scheme for mice. 7 Gy/day/mouse for 3 days of X-ray IR, NAM (1000 mg/kg) was given 24 h after last dose of IR. B. Representative pictures of tongues stained with TB and its histological analysis (HE stained), from control mice (non-irradiated, NR), and irradiated mice on day 10 after last dose IR, after they received vehicle (PBS) or NAM treatment; Scale bar 200 μm. C. Mean ulcer size percentage to the total epithelialized upper surface of the tongue. D. Quantification of the posterior epithelium height. Data presented as the mean ± SD (n=6). **P<0.01, ***P<0.001.