Table 1.
Main characteristics and results of the eligible studies of GEO, Oncomine and TCGA database
| Data source | Series | Author | Country | Platform | Source | Total sample | LUAD group | Control group | t | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||||||
| Number | Mean | SD | Number | Mean | SD | |||||||||
| GEO | GSE101929 | Mitchell | USA | GPL570 | tissue | 66 | 32 | 9.9831 | 0.6555 | 34 | 9.7959 | 0.5319 | 1.277 | 0.206 |
| GEO | GSE89039 | Zhang | China | GPL17077 | tissue | 16 | 8 | 2.0661 | 0.30253 | 8 | 1.8223 | 0.09485 | 2.175 | 0.06 |
| GEO | GSE75037 | Girard | USA | GPL6884 | tissue | 166 | 83 | 12.328 | 0.8279 | 83 | 11.5692 | 0.51708 | 7.082 | <0.001 |
| GEO | GSE69732 | Luo | Taiwan, China | GPL14951 | blood | 6 | 3 | 7.8316 | 0.59863 | 3 | 8.177 | 0.7698 | -0.614 | 0.573 |
| GEO, Oncomine | GSE68571 | Heiskanen | USA | GPL80 | tissue | 96 | 86 | 10.6057 | 0.70797 | 10 | 10.3465 | 0.27471 | 1.143 | 0.256 |
| GEO | GSE33532 | Meister | Germany | GPL570 | tissue | 100 | 40 | 8.5114 | 0.64197 | 20 | 8.1396 | 0.46914 | 2.547 | 0.014 |
| GEO | GSE21933 | Wang | Taiwan, China | GPL6254 | tissue | 42 | 11 | 10.5396 | 0.73921 | 21 | 9.8929 | 0.86131 | 2.112 | 0.043 |
| GEO | GSE29249 | Ma | China | GPL10558 | tissue | 12 | 3 | 9.9916 | 0.41926 | 3 | 10.1748 | 0.14972 | -0.713 | 0.515 |
| GEO, Oncomine | GSE32863 | Laird-Offringa | USA | GPL6884 | tissue | 116 | 58 | 12.2309 | 0.90385 | 58 | 11.443 | 0.50775 | 5.788 | <0.001 |
| GEO, Oncomine | GSE31210 | Kohno | Japan | GPL570 | tissue | 246 | 226 | 8.761 | 0.58791 | 20 | 8.5503 | 0.27429 | 2.897 | 0.006 |
| GEO | GSE20189 | Rotunno | USA | GPL571 | blood | 162 | 73 | 9.5296 | 0.80979 | 81 | 9.1888 | 0.7948 | 2.633 | 0.009 |
| GEO | GSE10799 | Streichert | Germany | GPL570 | tissue | 19 | 16 | 7.7469 | 0.65006 | 3 | 7.3571 | 0.23229 | 1.006 | 0.328 |
| GEO | GSE11117 | Budach | Switzerland | GPL6650 | tissue | 56 | 13 | 8.7007 | 0.74643 | 15 | 8.2783 | 0.7944 | 1.443 | 0.161 |
| Oncomine | GSE2514 | Stearman | USA | GPL8300 | tissue | 39 | 20 | 11.8006 | 0.27324 | 19 | 11.781 | 0.16047 | 0.275 | 0.785 |
| GEO | GSE1987 | Dehan | Israel | GPL91 | tissue | 37 | 7 | 11.4312 | 0.70249 | 7 | 11.7023 | 0.64842 | -0.75 | 0.468 |
| GEO, Oncomine | GSE10072 | Lee | USA | GPL96 | tissue | 107 | 58 | 8.956 | 0.4501 | 49 | 8.7295 | 0.48385 | 2.505 | 0.014 |
| GEO, Oncomine | GSE7670 | Su | Taiwan, China | GPL96 | tissue | 66 | 31 | 9.8428 | 0.73624 | 27 | 9.3547 | 0.4858 | 3.014 | 0.004 |
| TCGA | TCGA-LUAD | TCGA | USA | None | tissue | 562 | 503 | 13.375 | 0.605 | 59 | 13.174 | 0.321 | 4.06 | <0.001 |