Table 3.
GO functional annotations for most significantly co-expressed genes of BSG
| GO ID | GO term | Count (%) | P-Value | Genes symbol |
|---|---|---|---|---|
| Biological process | ||||
| GO:0006412 | translation | 47 (11.41) | 1.12E-22 | RPL18, NACA, MRPL41, RPL14, MRPS12, MRPS11, RPL35, RPS6KB2, RPL36, EIF5A,etc |
| GO:0006414 | translational elongation | 26 (6.31) | 6.05E-19 | RPL18, RPL14, RPL35, RPL36, RPLP2, EEF2, RPS5, RPL28, RPL29, RPS3, etc |
| GO:0022900 | electron transport chain | 20 (4.85) | 2.20E-11 | NDUFA2, NDUFA3, UQCRC1, NDUFB10, NDUFB7, NDUFA7, NDUFA13, NDUFC1, UQCRQ, NDUFA11, etc |
| GO:0006091 | generation of precursor metabolites and energy | 30 (7.28) | 3.83E-10 | ATP5D, ALDOA, UQCRC1, NDUFB7, ATP5G2, UQCRQ, ATP6V0B, NDUFS7, CYB561D2, NDUFS5, etc |
| GO:0006119 | oxidative phosphorylation | 17 (4.13) | 1.19E-09 | ATP5D, NDUFA2, NDUFA3, NDUFB10, UQCRC1, NDUFB7, NDUFA7, ATP5G2, NDUFC1, ATP6V0B, etc |
| GO:0006396 | RNA processing | 39 (9.47) | 2.83E-09 | POLR2F, POLR2E, PRPF4B, RPL14, POLR2L, PUSL1, POLR2I, LSM7, TRMT1, TRPT1, etc |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 13 (3.16) | 5.89E-09 | NDUFA2, NDUFA3, NDUFB10, UQCRC1, NDUFB7, NDUFA7, NDUFC1, NDUFS7, NDUFS5, UQCR11, etc |
| GO:0042773 | ATP synthesis coupled electron transport | 13 (3.16) | 5.89E-09 | NDUFA2, NDUFA3, NDUFB10, UQCRC1, NDUFB7, NDUFA7, NDUFC1, NDUFS7, NDUFS5, UQCR11, etc |
| GO:0022904 | respiratory electron transport chain | 13 (3.16) | 2.92E-08 | NDUFA2, NDUFA3, NDUFB10, UQCRC1, NDUFB7, NDUFA7, NDUFC1, NDUFS7, NDUFS5, UQCR11, etc |
| GO:0034470 | ncRNA processing | 20 (4.85) | 1.05E-07 | RPL14, EXOSC4, PUSL1, TRPT1, TRMT1, RRP9, EXOSC1, QTRT1, NOP10, URM1, etc |
| Cellular component | ||||
| GO:0030529 | ribonucleoprotein complex | 68 (16.50) | 2.03E-30 | RPL18, SRP14, MRPS34, MRPL41, PRPF4B, RPL14, LSM7, RPLP2, RPS6KB2, RPS3, etc |
| GO:0005840 | ribosome | 44 (10.68) | 3.18E-27 | RPL18, MRPS34, MRPL41, RPL14, MRPS12, MRPS11, RPL35, RPS6KB2, RPL36, RPLP2, etc |
| GO:0033279 | ribosomal subunit | 34 (8.25) | 7.89E-25 | RPL18, MRPL41, RPL14, MRPS12, MRPS11, RPL35, RPLP2, RPL36, RPS3, MRPL12, etc |
| GO:0005739 | mitochondrion | 79 (19.17) | 1.17E-18 | ATP5D, MRPS34, TSPO, MRPL41, PTGES2, UQCRC1, PRDX5, ROMO1, COX5A, C14ORF2, etc |
| GO:0022626 | cytosolic ribosome | 23 (5.58) | 1.88E-17 | RPL18, RPL14, RPL35, RPLP2, RPL36, RPS5, RPL28, RPS3, RPL29, RPS19, etc |
| GO:0015934 | large ribosomal subunit | 20 (4.85) | 1.37E-15 | RPL18, MRPL41, RPL14, RPL35, RPLP2, RPL36, RPL28, RPL29, MRPL23, MRPL12, etc |
| GO:0044429 | mitochondrial part | 52 (12.62) | 3.61E-15 | ATP5D, TSPO, UQCRC1, MRPL41, COX5A, UQCRQ, COX5B, NDUFAF3, NDUFS7, LONP1, etc |
| GO:0044445 | cytosolic part | 27 (6.55) | 4.53E-15 | RPL18, RPL14, PIK3C2A, RPL35, RPL36, PRDX5, RPLP2, RPS5, RPL28, RPL29, etc |
| GO:0005743 | mitochondrial inner membrane | 33 (8.01) | 4.25E-12 | ATP5D, UQCRC1, NDUFB7, MTX1, ATP5G2, COX5A, UQCRQ, COX5B, NDUFAF3, NDUFS7, etc |
| GO:0019866 | organelle inner membrane | 34 (8.25) | 6.11E-12 | ATP5D, UQCRC1, NDUFB7, MTX1, ATP5G2, COX5A, UQCRQ, COX5B, NDUFAF3, NDUFS7, etc |
| Molecular function | ||||
| GO:0003735 | structural constituent of ribosome | 39 (9.47) | 1.29E-27 | RPL18, MRPL41, RPL14, MRPS12, MRPS11, RPL35, RPL36, RPLP2, RPS3, MRPL12, etc |
| GO:0003723 | RNA binding | 46 (11.17) | 3.75E-10 | RPL18, SRP14, RPL14, PUSL1, LSM7, RPL35, EIF5A, RPLP2, TRMT1, CALR, etc |
| GO:0005198 | structural molecule activity | 41 (9.95) | 3.32E-09 | RPL18, MRPL41, CLTB, RPL14, MRPS12, MRPS11, RPL35, RPL36, RPLP2, RPS3, etc |
| GO:0016651 | oxidoreductase activity, acting on NADH or NADPH | 15 (3.64) | 4.27E-09 | NDUFA2, NDUFA3, NDUFB10, NDUFB7, NDUFA7, NDUFA13, CYB5RL, NDUFC1, ECSIT, NDUFS7, etc |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 11 (2.67) | 2.92E-08 | NDUFS7, NDUFS5, NDUFA2, NDUFA3, NDUFB10, NDUFB7, NDUFS8, NDUFA7, NDUFA13, NDUFC1, etc |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 11 (2.67) | 2.92E-08 | NDUFS7, NDUFS5, NDUFA2, NDUFA3, NDUFB10, NDUFB7, NDUFS8, NDUFA7, NDUFA13, NDUFC1, etc |
| GO:0003954 | NADH dehydrogenase activity | 11 (2.67) | 2.92E-08 | NDUFS7, NDUFS5, NDUFA2, NDUFA3, NDUFB10, NDUFB7, NDUFS8, NDUFA7, NDUFA13, NDUFC1, etc |
| GO:0015078 | hydrogen ion transmembrane transporter activity | 14 (3.40) | 1.05E-07 | ATP5D, UQCRC1, UQCR11, UQCRH, COX8A, COX6B1, COX4I1, COX6A1, ATP5G2, COX5A, etc |
| GO:0016655 | oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor | 11 (2.67) | 1.11E-07 | NDUFS7, NDUFS5, NDUFA2, NDUFA3, NDUFB10, NDUFB7, NDUFS8, NDUFA7, NDUFA13, NDUFC1, etc |
| GO:0015077 | monovalent inorganic cation transmembrane transporter activity | 14 (3.40) | 5.88E-07 | ATP5D, UQCRC1, UQCR11, UQCRH, COX8A, COX6B1, COX4I1, COX6A1, ATP5G2, COX5A, etc |