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. 2019 Aug 15;11(8):4935–4945.

Figure 5.

Figure 5

Circ_0039569 promotes RCC cell proliferation and metastasis via miR-34a-5p/CCL22. A, B. Down-regulation of circ_0039569 reduced RCC cell proliferation. RCC4 and 786-O cells were transfected with circ_0039569 siRNA or miR-34a-5p combined with or without CCL22 and the survival ability was analyzed by CCK8 assay. C. Down-regulation of circ_0039569 reduced migrated RCC cell numbers. RCC4 and 786-O cells were transfected with circ_0039569 siRNA, or miR-34a-5p combined with or without CCL22 and migration ability was analyzed by wound healing assay. D. Down-regulation of circ_0039569 reduced invaded RCC cell numbers. RCC4 and 786-O cells were transfected with circ_0039569 siRNA, or miR-34a-5p combined with or without CCL22 and invasion ability was analyzed by transwell chambers with matrigel treatment. Data were expressed as mean ± SD. **P < represents statistical difference.