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The scaffold structures of five reported series of small molecule apelin agonists from Amgen (Chen et al., 2017), Bristol-Myers Squibb (Myers et al., 2017), RTI International (Narayanan et al., 2016), Sanford-Burnham (Pinkerton and Smith, 2015), and Sanofi (Hachtel et al., 2014). CMF-019 is derived from the Sanofi series. All of these molecules possess a broadly similar structure, consisting of two hydrophobic groups (circled in pink) extending from a heterocyclic core group (in blue).
