TABLE 1.
Contacts between apelin-13 and the apelin receptor, inferred from the crystal structure PDBID 5VBL
| Apelin-13 Contact | Receptor Contacts | References |
|---|---|---|
| Q1 Sidechain | D92a | Gerbier et al., 2015 |
| Q1 Backbone | N177 | |
| P3 Sidechain | T22 | |
| D23a | Zhou et al., 2003a | |
| R4 Backbone | D23a | Zhou et al., 2003a |
| L5 Sidechain | E20a | Zhou et al., 2003a |
| T22 | ||
| S6 Sidechain | E174a | Chapman et al., 2014; Gerbier et al., 2015 |
| S6 Backbone | Y21 | |
| H7 Sidechain | E174a | Chapman et al., 2014; Gerbier et al., 2015 |
| K8 Sidechain | Y21 | Gerbier et al., 2015 |
| D284a | Ma et al., 2017 | |
| S275 | ||
| G9 backbone | Y271 | |
| P10 Sidechain | E198a | |
| L173 | Chapman et al., 2014 | |
| M11 Sidechain | W24 | |
| Y271a | Ma et al., 2017 | |
| F291 | ||
| K268b | Kumar et al., 2016 | |
| P12 Sidechain | W24 | |
| Y93 | ||
| P12 Backbone | R168a | Ma et al., 2017 |
| F13 Sidechain | W85a | |
| Y88 | ||
| T89 | ||
| Y93 | ||
| Y299 | ||
| F13 Carboxylate | K268b | Kumar et al., 2016 |
| Y264 |
a
Receptor residues implicated in apelin binding by mutagenesis.
b
Receptor residues affecting bias and internalization by mutagenesis.