Table 3.

Goodness-of-fit statistics in the patient cohort. The last column provides the p-values of the two-sided WRSTs searching for significant differences in these statistics between the subgroups of cured and biochemically relapsing patients. The level of significance was set at p < 0.05. IQR, interquartile range.

statistic	all patients (n = 71)			cured patients ( n= 64)			relapsing patients (n = 7)			WRST
	median	IQR	range	median	IQR	range	median	IQR	range	p-values
periodic-dose model
SSE (ng ml−1)2	0.15	(0.06, 0.81)	(0.00, 68.23)	0.15	(0.05, 0.68)	(0.00, 68.23)	1.27	(0.16, 1.69)	(0.04, 6.79)	0.121
R2	1.00	(0.98, 1.00)	(0.69, 1.00)	1.00	(0.98, 1.00)	(0.69, 1.00)	0.99	(0.98, 1.00)	(0.98, 1.00)	0.401
${\hat{R}}^2$	0.99	(0.97, 1.00)	(0.51, 1.00)	0.99	(0.98, 1.00)	(0.51, 1.00)	0.98	(0.97, 0.99)	(0.96, 1.00)	0.293
RMSE (ng ml−1)	0.19	(0.12, 0.42)	(0.01, 3.72)	0.18	(0.12, 0.38)	(0.01, 3.72)	0.50	(0.21, 0.82)	(0.14, 1.06)	0.063
single-dose model
SSE (ng ml−1)2	0.15	(0.04, 0.70)	(0.00, 68.24)	0.14	(0.04, 0.57)	(0.00, 68.24)	1.19	(0.16, 2.24)	(0.04, 6.09)	0.112
R2	1.00	(0.99, 1.00)	(0.70, 1.00)	1.00	(0.99, 1.00)	(0.70, 1.00)	0.99	(0.99, 1.00)	(0.97, 1.00)	0.284
${\hat{R}}^2$	0.99	(0.98, 1.00)	(0.52, 1.00)	0.99	(0.98, 1.00)	(0.52, 1.00)	0.98	(0.97, 0.99)	(0.95, 1.00)	0.228
RMSE (ng ml−1)	0.19	(0.11, 0.37)	(0.01, 3.72)	0.17	(0.09, 0.35)	(0.01, 3.72)	0.49	(0.21, 0.81)	(0.14, 1.01)	0.063