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. 2019 Sep 2;14:1579–1587. doi: 10.2147/CIA.S220283

Figure 4.

Figure 4

Exercise training (ET) restores the age-related decrease in the GSK1016790A-induced endothelium-derived hyperpolarizing factor (EDHF) response in rat aortic arteries. Representative traces (AC) and summary data (D) for 300 nmol/L GSK1016790A-induced EDHF-mediated relaxation in aortic arteries derived from rats in the Young, Old, and Old + ET groups. The EDHF response was induced by GSK1016790A (300 nmol/L) in the presence of indomethacin (7 μmol/L) and NG-nitro-L-arginine (300 μmol/L). Values are the mean ± SEM (n=3 experiments). *P<0.05 vs. Young; #P<0.05 vs. Old. Phe indicates phenylephrine; GSK, GSK1016790A.