Table 2.

Cytotoxicity of suramin analogues for human epithelial hTERT RPE-1 cells and colon cancer HCT116 cells.^a

compound	IC50, μMb		selectivity
	HCT116	hTERT RPE-1
NF157	38 ± 1	120 ± 16	3.2
NF546	91 ± 7	310 ± 30	3.4
suramin	109 ± 10	400 ± 22	3.7
PPADS	310 ± 20	400 ± 14	1.3
iso-PPADS	370 ± 30	560 ± 55	1.5

^aCytotoxicity of suramin analogues for hTERT RPE-1 and HCT116 cells was determined by measuring intracellular ATP concentrations. Selectivity = hTERT RPE-1 IC₅₀/HCT116 IC₅₀.

^bMean ± s.e.m. where n = 3.