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Coinhibition of CDK4/6 and PRMT5 is effective across several tumor types. Proliferation curves of MCF7 (A), MDA-MB-231 (B), HS578T (C) breast cancer cells, JHESO (D) esophageal cancer cells, and BXPC3 (E) pancreatic cancer cells treated with 1 μM (2 μM for HS578T) palbociclib, 500 nM GSK3326595, or combination of both drugs. Graphs are representative of 2 independent experiments. Error bars represent SEM for 3 technical replicates.
