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. 2019 Aug 20;116(36):17825–17830. doi: 10.1073/pnas.1821063116

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Fig. 2. — Evolutionary coupling scores of intermolecular pairs correlate with residue–residue interactions in simulations. (A) Clustered Pcdh half-dimer of EC1-2 and EC3-4 showing coevolving residue pairs across the EC1/EC4 (pink) and EC2/EC3 (green) interface. (B) Box plots of residue–residue distances for top 15 intermolecular pairs for all 4 simulations. Boxes are colored based on their location on the EC1/EC4 (pink) or EC2/EC3 (green) interface. (C) Heatmap of the fraction of time the top 15 intermolecular coevolving pairs are within 5 Å for the 4 simulations.