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. 2019 Aug 19;116(36):18021–18030. doi: 10.1073/pnas.1907447116

Fig. 3.

Fig. 3.

AD169-induced caspase-2 activation requires ATM and the PIDDosome. (A) ATM-PIDDosome signaling pathway of caspase-2 activation. (B) PIDD or RAIDD knockout and control (CTR) HFF were infected with HCMV AD169. Samples were collected 24 hpi and caspase-2 activation was analyzed using immunoblot analysis. (C) MRC-5 cells were pretreated with ATM inhibitor (KU-60019) for 1 h at indicated concentration, then infected by AD169. (D) ATM-deficient dermal fibroblasts and control cells were infected with AD169 and caspase-2 activation was analyzed. The data shown in this figure are representative of 3 independent experiments.